Two sample MR report
HLA-A_Monocyte (Mono) against finn-b-ASTHMA_ALLERG_EXMORE
Date: 13 January, 2026
Results from two sample MR:
| method | nsnp | b | se | pval |
|---|---|---|---|---|
| MR Egger | 27 | 0.2625340 | 0.1207144 | 0.0393096 |
| Weighted median | 27 | -0.0486705 | 0.0176326 | 0.0057755 |
| Inverse variance weighted | 27 | -0.0583931 | 0.0137843 | 0.0000227 |
| Simple mode | 27 | -0.0461778 | 0.0309546 | 0.1477885 |
| Weighted mode | 27 | -0.0455394 | 0.0311011 | 0.1551172 |
Heterogeneity tests
| method | Q | Q_df | Q_pval |
|---|---|---|---|
| MR Egger | 4.318551 | 25 | 0.9999988 |
| Inverse variance weighted | 11.479895 | 26 | 0.9937427 |
Test for directional horizontal pleiotropy
| egger_intercept | se | pval |
|---|---|---|
| -0.1452803 | 0.0542887 | 0.0129552 |
Test that the exposure is upstream of the outcome
| snp_r2.exposure | snp_r2.outcome | correct_causal_direction | steiger_pval |
|---|---|---|---|
| 0.0007178 | 0 | TRUE | 0.0109418 |
Note - R^2 values are approximate
Forest plot of single SNP MR
Comparison of results using different MR methods
Funnel plot
Leave-one-out sensitivity analysis
